Weihua Guan, PhD

My research focuses on statistical genetics and the identification of genes involved in complex diseases and traits, with a special emphasis on developing statistical and analytical methods for the genetic data with new high-throughput technologies.

• 2016–2018, NIH Nat'l Inst of Child health/Human Dev, "Offspring genome wide DNA methylation patterns at birth and the intrauterine environment in the EAGeR Trial," Co-Investigator
• 2013–2017, Leukemia and Lymphoma Soc, "Biomarkers of Frailty and Its Impact on Geriatric HSCT Outcomes," Co-Investigator
• 2013–2017, NIH NCI, "An Integrated Study of Mitochondrial Pathways in Colorectal Cancer," Co-Investigator

See a full list of publications on PubMed

Selected Recent Publications

• Yoon G, Zheng Y, Zhang Z, Zhang H, Gao T, Joyce B, Zhang W, Guan W, Baccarelli AA, Jiang W, Schwartz J, Vokonas PS, Hou L, Liu L. "Ultra-high dimensional variable selection with application to normative aging study: DNA methylation and metabolic syndrome," BMC Bioinformatics, March 2017
• Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, et al. "Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach," PLoS Medicine, Jan 2017
• Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, et al. "DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases," Genome Biology, Dec 2016
• Ho YY, Guan W, O'Connell M, Basu S. "Powerful association test combining rare variant and gene expression using family data from Genetic Analysis Workshop 19," BMC Proceedings, Oct 2016
• Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, et al. "Epigenetic Signatures of Cigarette Smoking," Circulation: Cardiovascular Genetics, Sept 2016