Joseph Koopmeiners, PhD

Professor and Division Head, Division of Biostatistics

Joseph Koopmeiners

Contact Info

Office Phone 612-624-7486

Office Address:
Mayo A464

Mailing Address:
420 Delaware St. SE
Minneapolis, MN 55455

Professor and Division Head, Division of Biostatistics

Member, Masonic Cancer Center (MCC)

PhD, Biostatistics, University of Washington, 2009

MS, Biostatistics, University of Minnesota, 2004

BA, Mathematics, St. John's University


I develop statistical methods to answer questions related to cancer prevention, detection, and treatment more accurately and efficiently. To do this, I combine statistical methods research in the areas of biomarker validation and Bayesian adaptive methods for clinical trials. 



Awards & Recognition

  • Delta Omega, Honorary Society in Public Health

Professional Associations

  • American Statistical Association
  • International Biometrics Society
  • Society for Clinical Trials


Research Summary/Interests

My methods research is strongly related to my collaborations in the University of Minnesota Masonic Cancer Center and is currently focused on the following areas:

  • Biomarker Validation
  • Detection of Prostate Cancer Using MRI
  • Tobacco Regulatory Science
  • Early Phase Cancer Clinical Trials

Research Funding Grants

  • 2015–2018, DOD, "Development of a Multiparametric MRI Model of Clinically Significant Prostate Cancer," Principal Investigator
  • 2016–2018, NIH, "Innovative Statistical Methods for Detecting and Accounting for Non-Compliance in Randomized Trials of Very Low Nicotine Content Cigarettes," Principal Investigator
  • 2017–2022, NIH, "Evaluating New Nicotine Standards for Cigarettes," Co-Director of Biostatistics Core
  • 2015–2017, NCCF, "Preclinical Evaluation of Clinical Translation in Novel Bispecific Targeted Toxins for the Treatment of Sarcomas," Co-Investigator
  • 2015–2017, CDC, "Healthy Youth Development Prevention Research Center - Special Interest Project Competitive Supplement," Co-Investigator
  • 2014–2019, NIH, "Chemical Markers of Heterocyclic Aromatic Amines for Human Biomonitoring," Co-Investigator
  • 2014–2017, NIH, "Carcinogen DNA Adduct Biomarkers in Formalin Fixed Tissues," Co-Investigator
  • 2012–2017, NIH, "Development of an Optimal MRI Platform for Prostate Investigations at 7 Tesla," Co-Investigator
  • 2012–2019, NIH, "Cancer Center Support Grant," Member, Biostatistics and Bioinformatics Shared Resource
  • 2016–2021, NIH, "NK Cells, Their Receptors, Transplantation and Cancer Therapy," Statistician


See a full list of my publications on PubMed

Selected Publications

  • Tidey JW, Pacek LR, Koopmeiners JS, Vandrey R, Nardone N, Drobes DJ, Benowitz NL, Dermody SS, Lemieux A, Denlinger RL, Cassidy R, al'Absi M, Hatsukami DK, Donny EC. "Effects of 6-week Use of Reduced-Nicotine Content Cigarettes in Smokers With and Without Elevated Depressive Symptoms," Nicotine & Tobacco Research, January 2017
  • Rupprecht LE, Koopmeiners JS, Dermody SS, Oliver JA, al'Absi M, Benowitz NL, Denlinger-Apte R, Drobes DJ, Hatsukami D, McClernon FJ, Pacek LR, Smith TT, Sved AF, Tidey J, Vandrey R, Donny EC. "Reducing Nicotine Exposure Results in Weight Gain in Smokers Randomised to Very Low Nicotine Content Cigarettes," Tobacco Control, November 2016
  • Koopmeiners JS, Hobbs BP. "Detecting and Accounting for Violations in Constancy Assumption in Non-Inferiority Clinical Trials," Statistical Methods in Medical Research, September 2016


Teaching Areas

I teach in the Biostatistics (MPH, MS, PhD) program and advise master's and PhD students. 


  • PubH 7420, Clinical Trials: Design, Implementation, and Analysis


In The News

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